This paper delves into the intricate impacts between economic freedom indices and the bank efficiency of regional development banks (BPDs) in Indonesia. The research focuses on three key independent variables of Investment Freedom (INV), Monetary Freedom (MON), and Business Freedom (BUS) to elucidate their influence on Bank Operational Expenses and Revenues (BOPO), a crucial indicator of operational efficiency. This analysis itself has yielded intriguing findings by leveraging a panel dataset encompassing 24 BPDs listed by the Otoritas Jasa Keuangan (OJK) with complete financial reports from 2017 to 2021, the research utilizes data panel regression analysis within EViews software. As the results, contrary to initial expectations, Investment Freedom did not exhibit a partially significant impact on BOPO. This warrants further exploration of potential moderating factors specific to the Indonesian context. Conversely, Monetary Freedom demonstrated a statistically significant negative association with BOPO, suggesting that while central bank autonomy offers potential benefits, potential drawbacks associated with excessive risk-taking behaviour require careful consideration. Encouragingly, Business Freedom emerged as a significant and positive driver of BPD efficiency, highlighting the importance of deregulation and streamlined processes in fostering a more competitive and innovative banking landscape. By fostering a deeper understanding of the factors influencing BPD efficiency, this research can contribute to the development of more effective policies for a thriving regional banking sector that roles vitally in supporting the economic growth and development in Indonesia.