Abstract

Hyperglycemia is a condition where blood sugar levels to rise which will eventually become a disease called diabetes mellitus (DM) is a disorder caused by the body lacks insulin, glucose remains consequently circulate in the bloodstream and difficult to penetrate the cell wall. Treatment to lower blood glucose levels either by utilizing plants as traditional medicine. This study aims to determine the yield, secondary metabolites and the activity of ethyl acetate fraction luffa fruit in lowering blood glucose levels in male rats. Extraction is done by maceration using 80% ethanol. Fractionation performed using liquid-liquid fractionation. The subject of research in the form of white male rats of 15 rats were divided into 5 groups: negative control group using Na-CMC1%, the positive control group using glibenclamide 5 mg with a dose of 0.09 mg / 200grBB and ethyl acetate fraction fruit gambas with dosage variants ( 15 mg/200gBW; 20 mg/200gBW and 30 mg/200gBW) were administered orally with a glucose tolerance test method. Data obtained from the examination of fasting blood sugar levels, 30 minutes after induction of glucose and at minute 0, 30, 45, 60, 90, and 150 after being treated. The yield of ethyl acetate fraction obtained as much as 0.793%. Class of secondary metabolites were detected in the ethyl acetate fraction is the luffa fruit alkaloids and phenols.
Keywords:Alkaloids, Blood Glucose Tolerance Test, Hyperglycemia, Phenols.